![]() Individualize dose and closely monitor during up-titration double dose q2Weeks to the highest dosage level tolerated or up to 200 mg.Not suitable for initial therapy in patients who are expected to require a starting dose less than 25 mg/day. ![]() Initial dose: 25 mg PO qDay for 2 weeks.Prior to initiation, stabilize dose of other heart failure drug therapy and ensure patient is not fluid overloaded.New York Heart Association (NYHA) class ≥II: Reduce dosage 12.5 mg/day. ![]()
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